It will launch in April with two titles featuring Spider-Man and the Avengers, and will be aimed specifically at younger readers.
"The Marvel Universe line of comics not only clearly lets fans know they're in for great stories, but also lets parents know where to find great stories to share with their kids," said Axel Alonso, Marvel Comics' editor-in-chief.
"The Marvel Universe line also includes the best all-ages stories we've told recently and we're bringing them to millions of new fans through ambitious new initiatives.
"So when you see the name Marvel Universe, you'll know it stands for the best all-ages superhero storytelling in the world - in print and digital media."
Marvel Universe: Ultimate Spider-Man will feature a creative team of Man Of Action, Dan Slott, Ty Templeton and Nuno Plati.
Chris Yost and Adam Dekraker will produce Marvel Universe: The Avengers: Earth's Mightiest Heroes, which will include two stories seen through the eyes of S.H.I.E.L.D.'s Agent Coulson.
Marvel recently announced a Marvel Universe programming block for the Disney XD channel.