The 30 Days of Night creator will team with Tony Harris (Starman, Ex Machina) on Chin Music.
The publisher also confirmed Niles's collaboration with Scott Morse (Soulwind), Crime and Terror. The series was first revealed about a year ago.
The two titles were unveiled at Image Expo in Oakland, California, on Friday (February 24).
"It's a 1930s noir, gangster, horror story," wrote Harris on Twitter regarding Chin Music.
Crime and Terror is a horror comic centring around the strange life of detective Mike Fallon, featuring some supporting stand-alone short stories.
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Niles recently announced his new Dark Horse Comics title Nosferatu Wars.
Image also announced a third Phonogram miniseries and Grant Morrison's debut project for the publisher, Happy!