Chris Roberson and Michael Allred's ongoing title will end with issue #28.
"I'm just excited that I heard we can tell people it's reaching its awesome conclusion," said Allred during the Vertigo: New Blood panel at Emerald City Comicon.
"It's really thrilling to be able to put all of these events into my backyard, and so when the sky opens up and space monsters come spilling out into my neighborhood, it's something I've never been able to do before. So, it's a lot of fun."
The off-beat series centres around Gwen Dylan, a zombie who is forced to eat the brains of the dead to retain her humanity.
The supporting cast includes a were-terrier, a ghost, an Egyptian mummy and an organisation of monster hunters.
iZombie #23 was released on March 7, with issue #24 following on May 4.
> 'Saucer Country' will offend One Million Mums, says writer
> Vertigo unveils 'Mystery in Space'