The Game of Thrones actress will portray lead character Sela Mathers in the comic book adaptation, which is seeking funding through Kickstarter.
Zenescope has teamed up with Titmouse Animation Studio and director Jon Schnepp to launch the project. The publisher has until May 1 to raise the required $175,000 (£110,000) to finance the venture.
"We set the goal of the animated series at $175,000 because we wanted to give our fans and those supporting the Kickstarter a high-quality product." said Zenescope marketing manager Stephen Haberman.
"We're hiring Titmouse, one of the premiere animation studios in the world, to handle the animation. We have Jon Shnepp directing and now with Lena and Briana joining the project, we're able to take it to another level."
Editor-in-chief Ralph Tedesco added: "Crowd-funding can be a powerful tool. We've seen some really [great] projects find funding through Kickstarter and it's a game changer.
"It gives us a chance to make this series the way our fans want to see it be made. We're about a third of the way there with funding and hopefully now with the all of the talent we've brought on board fans will see that this can be an amazing project to back."
Zenescope's Grimm Fairy Tales page is live over on Kickstarter now.
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