The Ultimate Spider-Man artist expressed excitement about working on her first comic starring Peter Parker.
Spider-Men sees a team-up between the heroes of two different realities.
Pichelli joined the alternate Ultimate Comics title following the death of that universe's iteration of the original Spider-Man and his replacement with Miles Morales.
"Since Miles was created, I've been working hard on giving him a specific character, body language, attitude, etc, - but let's be honest, every artist gives something of themselves to the characters they create, and there's obviously something of me in Miles, too," she told Comic Book Resources.
"All the physical reactions and facial expressions of him are filtered by my idea of how they have to be, because what we draw is what we are - so in some way it's like I'm coming face to face with Peter Parker. And guys - it feels insanely cool!
"I don't have much experience with Peter Parker, so in these five issues of Spider-Men I've worked hard to find the right connection with him," Pichelli continued. "I'm trying to find the right elements of his character that could fit well with the story.
"I've chosen to underline the difference between the two Spider-Men. Miles is a young, newborn superhero, insecure and clumsy sometimes during the action. On the other hand, Peter is older and wiser. He has much more experience.
"He knows what to do and how to do it - but this time his self-confidence as Spider-Man is not the same because in Spider-Men he has to face a reality where all his reference points have been shattered. So I had to work on a big range of mixed emotions."
It was recently revealed that Mysterio will be the main villain of the Brian Michael Bendis-penned Marvel Comics miniseries.
Spider-Men #1 will debut in June.