The publisher's single-issue digital releases will now be available exclusively through the distributor's platforms under the terms of the multi-year deal.
"As the industry leader, Marvel is committed to growing the comics market through digital innovation - and bolstering our existing partnership with comiXology continues that," said Peter Phillips, SVP and general manager, Marvel Digital Media.
"This agreement is a huge win for current and future fans of the Avengers, X-Men, Spider-Man and Marvel's entire library of exciting characters."
Marvel's digital library will still be available through the firm's official apps, and the new web-based Marvel Comics Shop, both of which are powered by comiXology. The publisher's catalogue is also available through the desktop and mobile editions of the comiXology platform.
Starting today, Marvel titles will be available through comiXology's Digital Storefronts for brick-and-mortar retailers.
"We're extremely proud that Marvel has chosen comiXology as its partner," said David Steinberger, CEO of comiXology. "Our expanded relationship will foster increased innovation and accelerate plans for more points of distribution and reading. I'm more than thrilled."
Marvel adopted the day-and-date business model in November last year, which saw all new releases land in stores and digital outlets simultaneously.