The publisher unveiled a simple teaser image for the project, which will arrive in August.
Promising more information to be released on Monday on its official website, Marvel encouraged fans to speculate on Twitter with the #firstxmen hashtag.
Technically speaking, the first X-Men were Jean Grey, Cyclops, Beast, Ice-Man, Angel and their mentor Professor X.
The characters were created by Stan Lee and Jack Kirby in 1963's The X-Men #1.
The mutant team currently stand divided following X-Men: Schism and are being drawn into a battle with their superhero contemporaries in the events miniseries Avengers vs. X-Men.
No more information regarding The First X-Men has been revealed.