The comedian, actor and writer will lift the lid on the project at this weekend's Kapow! Comic Con in London.
Details of the project are being kept under wraps, though the illustrator Serafinowicz is collaborating with is said to be famous for his work on DC Comics' Batman.
DC announced earlier this week that it will hold a Before Watchmen panel at the event, where co-publisher Dan DiDio, editor Will Dennis and senior vice president of sales Bob Wayne will discuss the much-anticipated prequel.
Marvel Comics, Image Comics and 2000AD panels will also be held at Mark Millar's expo. Celebrity guests include Nick Frost, Frankie Boyle, Jimmy Carr, Russell Tovey and Jonathan Ross.
Kapow! Comic Con takes place on May 19 and 20 at the Business Design Centre in Angel, London.