Vintage titles including Crime Does Not Pay, Adventures into the Unknown and Forbidden Worlds will be reissued with colour restoration and forwards from contemporary creators.
"The comics found in these collections are incredibly hard to find, expensive, and full of freewheeling, pre-Code fun (and sometimes viscera)," said Dark Horse editor Philip Simon.
"It's a joy to be able to handle these comics and work on these collections - but a bigger joy comes from being able to bring these stories to new readers and to finally assign credits to some creators who have been uncredited for decades."
Writers and artists including Greg Rucka, Howard Chaykin and Michael T Gilbert will provide introductions for the re-released volumes.
Adventures into the Unknown Archives Volume 1 will kick off the line of reprints on May 30.