The publisher won the gong for 'Best Series' for Detective Comics, while Batman scribe Scott Snyder was honoured in the 'Best Writer' category.
Snyder also saw off competition from Jim Lee, Jane Goldman and Robert Kirkman to take home a 'Man or Woman of the Year' accolade, and accepted a 'Best Comic Hero' award on behalf of Batman.
DC was named as 'Publisher of the Year', but rivals Marvel Comics landed three awards, claiming 'Best Limited Series or Story Arc' with Uncanny X-Force: The Dark Angel Saga, as well as 'Best Newcomer' and 'Best Artist' gongs for Ultimate Comics Spider-Man illustrator Sarah Pichelli.
Image Comics bagged 'Best Trade' for The Walking Dead Volume 14: No Way Out.
Batman: Arkham City was named as 'Best Game or Toy of the Year', edging out The Elder Scrolls V: Skyrim, Portal 2 and L.A. Noire.
Game of Thrones was named as 'Best TV Show', while X-Men: First Class landed 'Best Superhero or Sci-Fi' movie.
The Stan Lee Awards were handed out during a ceremony this evening at Mark Millar's Kapow! Comic Con, presented by comedian Billy Kirkwood.