JH Williams III, Tom Richmond, Ben Katchor and Jon Rosenberg were among those honoured at the annual event, reports Robot 6.
MAD Magazine contributor Richmond received the Reuben Award for Outstanding Cartoonist of the Year.
Williams was named in the comic books category for his work on DC Comics' Batwoman.
Katchor won the graphic novel award for The Cardboard Valise, and Rosenberg took the online comic strip category for his webcomic Scenes from a Multiverse.
The 66th annual event was held in Las Vegas, Nevada, over the weekend.
The Reuben Awards are named for the National Cartoonists Society's first president, Rube Goldberg.