The publisher will release a commemorative edition of the comic featuring a new cover by Phil Jimenez at this year's Comic-Con International in San Diego.
"Life With Archie #16 is a landmark issue for Archie and comics in general. We broke new ground with the wedding of Kevin Keller and Clay Walker and we want to commemorate it at the biggest comic book event of the year - San Diego Comic-Con," Archie co-CEO Jon Goldwater told Bleeding Cool.
"Now, fans can get their hands on an exclusive copy of the issue, comic book-sized, featuring a beautiful cover by superstar Phil Jimenez.
"We have no plans to reprint this issue as a standalone again, so this is a unique opportunity to get a piece of comic book history."
Life With Archie #16 became the subject of a protest by conservative Christian group One Million Mums, who objected to its content and demanded it was withdrawn from sale.
Comic-Con International 2012 takes place at the San Diego Convention Centre between July 12 and 15.