The concluded part of his latest storyline uses a character based on JK Rowling's lead to satirise the publishing industry.
"Though the words 'Harry Potter' are never mentioned, the allusions are unmistakable," said The Independent, which received an advanced copy of the book.
"One section features a magical train hidden between platforms at King's Cross station which leads to a magical school. The antichrist character has a hidden scar and a mentor named Riddle. (Lord Voldemort, born Tom Riddle, is Harry Potter's arch enemy in the Potter series.)
"Characters resembling both Ron Weasley and Hermione Granger also appear and, at one point, the Potter character kills someone with a lightning bolt from his flaccid penis."
The Independent's reviewer Laura Sneddon was quick to defend the portrayal in the Kevin O'Neill illustrated book.
"The headlines almost write themselves - 'Alan Moore says Harry Potter is the antichrist!' - yet they miss the point," she said.
"When the antichrist is met, overgrown and high on anti-psychotics, raging at the education system that let him down and sounding peculiarly like Harry Enfield's teenage Kevin, he is surely no stand-in for one particular character but of the current obsession for replacing stories with money-generating franchises.
"Today, film rights are bought before publication, comics are written as storyboards, and teenage celebrities are given memoirs. What better representative of modern pop literature than JK Rowling's boy wizard?"
The League of Extraordinary Gentlemen: Century 2009 follows years 1910 and 1969, and will be released tomorrow (Wednesday June 20) by Top Shelf Productions.