Marvel Comics will team the Incredible Hercules writer with Alessandro Vitti (Secret Warriors) for the festive one-shot.
Following on from a series of increasingly over-the-top Marvel Zombies titles, Van Lente has promised a "classic zombie apocalypse story" focusing on a boy and his mother.
"The kid has grown up in a zombie apocalypse universe and when Halloween rolls around, he wants to go trick or treating," he told Comic Book Resources.
"He's heard about it and read about it, but his mum doesn't think it's a very good idea because they're surrounded by zombies.
"So he asks her, 'What's the purpose of us staying alive during the zombie apocalypse if we never get to have any fun? What's the point of just surviving?' He then sneaks out on Halloween night and goes Trick or Treating in a Spider-Man costume and events spiral from there. It's a horrific but sweet little tale."
Van Lente contributed to the Marvel Zombies and Marvel Zombies Return miniseries. He previously collaborated with Vitti on Fear Itself: The Home Front.
He is also writing the forthcoming Valiant Comics revival of Archer & Armstrong.