Jonathan Maberry will return for the four-part miniseries, following on from his Marvel Universe Vs. The Punisher and Marvel Universe Vs. Wolverine outings.
Northlanders and New Mutants artist Leandro Fernandez will join him on the horror title, which sees Marvel's heroes infected by a plague that turns them into maddened cannibals.
"The story is told from Hawkeye's perspective, but most of the big guns are there: Thor, Hulk - red and green versions - Iron Man, Giant Man, Luke Cage, Black Widow, Mockingbird, Spider-Man, and others," Maberry told Marvel.com.
"We also check in on the kids at Avengers Academy. The events in these four issues cut a bloody swath across the entire Avengers landscape.
"The world is becoming a horror show and no-one has the power to stop it."
Marvel Universe Vs. The Avengers will debut in October.