The classic literature character will play a "pivotal" role in the series, joining the fray in issue #3 of the crossover title.
Dracula vs. Robin Hood vs. Jekyll & Hyde is produced via the publisher's range of Eco Comics, entirely paperless titles designed to have minimal negative impact on the environment and wildlife.
Writer Chris Bunting said: "Frankenstein's Monster will play a pivotal role, not just in this series, but in a subplot bubbling away that will encompass many other titles from Eco Comics.
"You will see Frankenstein in a way never portrayed. And this monster is not this issue's only legendary guest star, as a colossal character from the Robin Hood myth is also introduced."
All three issues of Dracula vs. Robin Hood vs. Jekyll & Hyde are available to purchase in digital via the Mohawk website.