The John Cassaday artwork - featuring Thor, Havok, Scarlet Witch, Rogue, Captain America and Wolverine - was previewed by Entertainment Weekly.
The title will be written by Rick Remender as part of Marvel Comics' newly-unveiled Marvel NOW! initiative.
The comic features a new team comprised of X-Men and Avengers members struggling to make peace following the events of Avengers vs X-Men.
The Uncanny Avengers will go up against a new iteration of the Red Skull in the first storyline.
"I'm not just smashing the heroes together, I'm smashing the villains together," said Remender.
"It becomes something unlike anything we've ever seen, with stakes that are so huge, it takes a team comprised of the best Avengers and the best X-Men to go take care of it."
New Avengers and All-New X-Men titles will also debut under the new banner.
Uncanny Avengers #1 will be released in October.