John Arcudi will write the five-issue miniseries alongside artist Max Fiumara, continuing the story from the 1946 and 1947 miniseries.
The story follows Trevor Bruttenholm and his team into New Mexico.
"[B.P.R.D.: 1948] takes place at a military facility in the New Mexico desert during some rather unusual nuclear testing: the use of low-grade nuclear bombs to propel spacecraft," Arcudi told Comic Book Resources.
"It's loosely based on the actual events surrounding Project Orion - perhaps as a result of these tests, Professor Bruttenholm and a B.P.R.D. crew (fronted by Stegner and Anders) come to New Mexico to investigate a strange series of sightings of some horrifying monsters.
"There, the Professor meets Anna Rieu, a brilliant and beautiful physicist. Seems like a match made in heaven, and sparks do fly - but all kinds of sparks! Meanwhile, Anders proves to be a smouldering problem that comes to head at maybe the worst possible time."
The previous two miniseries were written by Joshua Dysart and B.P.R.D. creator Mike Mignola.
B.P.R.D.: 1948 will launch in October.