The SIP project will mark the 20th anniversary of the acclaimed comic, the writer and artist revealed at San Diego Comic-Con International, reports Comic Book Resources.
"I'm approaching 60 and I don't want to be 65 with a monthly deadline for art pages," said Moore.
"I'm thinking about my future - I can be 75 and still write. [The readers] have matured, so I would like to write a deeper, more introspective story."
He also revealed that his current Rachel Rising series will conclude in 30 to 40 issues to make way for an all-ages project.
"I want to do an all-ages funny thing again," he said. "I'm happiest when I'm drawing something funny or silly - I'm actually a funny guy. There's still a kid in me. [I want] to focus on life and how it's like yours, but funnier. [My characters] can laugh at themselves.
"I have this urge to remind people that life can be beautiful and funny."
The development of the Strangers in Paradise novel means that Moore will only attend San Diego Comic-Con this year.
The book will be released in 2013 through his company Abstract Studios.