The collection will compile classic illustrations from MAD artists including Basil Wolverton, Harvey Kurtzman, Will Elder and Wally Wood.
"You can't understate the importance of Harvey Kurtzman and MAD comics to American culture," editor Scott Dunbier told CBR.
"If you go back and look at how many people were influenced by MAD - as both a comic, and later as a magazine, it's sort of staggering."
He added: "All of the underground cartoonists cite Kurtzman and MAD as a huge influence... I think the landscape of pop-culture would have been a lot different if it wasn't for MAD."
IDW secured a licensing deal with DC Comics to make the collection possible. MAD Magazine editor-in-chief John Ficarra is said to have been instrumental in getting the comic book giant on side.
MAD: Artist's Edition is released in December to coincide with MAD's 60th Anniversary.