Grant Morrison made a similar announcement earlier in the week.
Veteran Image Comics founder Liefeld tweeted that he "will be close behind".
"As for DC work, I've done my job, stopped the bleeding, revived the patient... enjoying my collaborations..." he continued.
"Lots of creator owned dreams yet to realise..."
The writer and artist will conclude his work on DC Comics' Deathstroke, Hawkman and Grifter next year, adding that that was "a ways off".
Morrison has revealed that he will end his current work for DC with Action Comics #16 and Batman Incorporated #12.
A string of top creators have recently announced their intention to end their work-for-hire superhero projects to focus on creator-owned comics.
"The current corporate comics conditions are an absolute bear, on both sides, for both Big Two," tweeted Liefeld. "Not a political statement #fact."
"Gotta say, for me personally, working at DC this past year has been ridiculously enjoyable and fun," he added. "Treats talent right."