The superstar comics writer will give an hour-long talk at the Northants International Comics Expo 2012 (NICE).
The debut comics convention's guest of honour will follow up his talk with a Q&A session that will last another hour.
The guest list also includes Charlie Adlard, Simon Bisley, Doug Braithwaite, Ian Churchill, Alan Davis, Steve Dillon, Marko Djurdjevic, Glenn Fabry, Melinda Gebbie, RM Guera, Adi Granov, David Hine, Shaky Kane, Dave Kendall, Clint Langley, Ben Oliver, Esad Ribic, Greg Staples and John Watson.
Attendees at the panels will be required to make a mandatory donation of graphic novels to Northamptonshire Libraries, showing proof of their donation upon entry to the events.
The V for Vendetta and From Hell writer has been in the spotlight of late following the debut of DC Comics' controversial prequels to his legendary Watchmen series.
Top Shelf Productions recently announced a publication of Moore's Unearthing.