Writers Brian Posehn, Gerry Duggan and artist Tony Moore will tackle the relaunching title for the Marvel NOW! initiative.
The team was teased last week with the word "Chimichangas".
"It's an action/comedy, but I would say the DNA is in Big Trouble in Little China and Ghostbusters and those sorts of things where the stakes are high and these are real threats," Duggan told IGN.
"If Deadpool can't get the job done, this country is done. There are big threats."
The first storyline will see Deadpool go up against zombie versions of US presidents.
"Hopefully America is good and sick of politics. Hopefully you won't mind seeing some of the former pillars of society and government come back with some very bad intentions."
Deadpool creator Rob Liefeld caused a backlash on Twitter last week when he complained about "D-list talent" writing his character.
Deadpool #1 will arrive in November.