The Cartoon Network writer, producer, director and voice actor will team Deadpool with Peter Parker in his two-issue story for the title.
"I met Marvel editor Steve Wacker at Comic-Con about a year ago," Shinick told Comic Book Resources. "I think he was dressed as Mystique.
"Anyway, he told me that he and his family were big fans of my show MAD and we talked about possibly doing a comic together. I told him I was a huge fan of Spider-Man, that I had done this immense stage show and that I would absolutely love to write an actual Spider-Man comic.
"So of course he gave me… Deadpool! He said, 'I have an idea, Deadpool in high school'. I said, 'That's great! I have no idea what that means'.
"My problem being A) Deadpool wasn't Deadpool in high school and B) Part of Deadpool's mystique is not quite knowing his origin and I didn't want to be the jack ass that changed that. Grasping at straws I said, 'Can I at least put him in Peter Parker's high school to ground it someplace?'"
Shinick also directed Peter Parker's full-length stage debut in 2002's Spider-Man: Live.
He will be joined by artist Aaron Kuder (Amory Wars) on Avenging Spider-Man #12, which debuts on September 12.