The writer/artist has abruptly abandoned his three titles - Hawkman, Deathstroke and Grifter - all of which he will depart after September's issue #0s.
"Just finished sending my thank you's to DC personnel. Officially got off the DC52 treadmill this morning..." Liefeld wrote on Twitter.
"Scott Clark will be replacing me [on] Deathstroke. Marat will continue the work on Grifter.... I had a great time at DC. I believe in what DC is doing, but had to preserve my sanity.
"I walked off all 3 books. Can't wait to see any attempts to spin. I have every email. This is the 4th time I quit in the last 4 months. This time it will stick."
Liefeld offered a series of complaints about his editor, saying that he "lasted a few months longer than I thought possible" and promising "the best stuff" regarding his gripes was yet to be revealed.
He had previously promised to refocus himself on his creator-owned work over the coming year.
Liefeld's complaints echo those of George Perez, who departed Superman earlier in the year, siting issues with editorial interference and disorganisation.