The Savage Dragon creator will step down as writer and artist on the creator-owned title after issue #68, according to one of his recent Twitter posts.
"After much thought I've decided to end my run on Supreme with issue #68 and make it an 80-page giant. I can do more cool s**t that way," he wrote.
"Supreme #68 won't be all one big story there'll be solo stories for Squeak, Sister Supreme, Lion-Headed Supreme and Original Supreme as well."
Larsen went on to praise Supreme creator Rob Liefeld for his hands-off approach to the title, and expressed his desire to embark on some creator-owned ventures himself.
"Make no mistake, I had a ball on Supreme and Rob Liefeld has been extremely supportive and hands off. He's let me run wild with it," he added.
"But the reality is - I have a million things of my own I want to do and I can't do everything. Something had to give. I have a project or two in the works that I keep having to put off."
Supreme is released in October 3.