The cover and interiors of the forthcoming miniseries were posted on Comic Book Resources.
The issue heralds the return of creator Mignola to interior artwork for his best-known creation.
"After saving the world in The Storm and The Fury, but sacrificing himself and Great Britain, Hellboy is dead, cast into Hell, where he finds many familiar faces, and a throne that awaits him," reads Dark Horse Comics' solicitation.
"Mike Mignola returns to draw Hellboy's ongoing story for the first time since Conqueror Worm. It's a story only Mignola could tell, as more of Hellboy's secrets are at last revealed, in the most bizarre depiction of Hell you've ever seen."
Mignola has denied rumours that there will be a third Hellboy movie.
Hellboy in Hell #1 will be released on December 5.