Ain't It Cool News was the first to report that the Scalped artist has joined the project, and DC Comics later confirmed the appointment via its official blog.
A writer for the five-issue miniseries is yet to be announced, but the publisher has revealed that Jim Lee will provide a variant cover design for issue #1.
Django Unchained is based on the upcoming Quentin Tarantino movie of the same name. It will be directly adapted from its screenplay, meaning that scenes cut from the final film will make it into the comics.
The movie, which sees a slave-turned-bounty-hunter set out to rescue his wife from a brutal Mississippi plantation owner, features an all-star cast spearheaded by Leonardo DiCaprio, Samuel L Jackson, and Jamie Foxx.
The Django Unchained comic will debut in November, with the film following in December in the US and in the UK in January 2013.
Watch the movie's trailer below: