Dennis Hopeless and Salvador Larroca's new team book will fall under the Marvel NOW! banner.
It sees a group of mutants on the run from the authorities under the leadership of fan favourite Cable.
"The X-Force that Cable's leading is a group of outlaws trying to save the world," Hopeless told Marvel.com.
"They're fugitives being chased across the globe and doing what good they can while always looking back over their shoulders. There's not much room for error on this team."
The new X-Force will also feature Colossus, Domino, Forge and Dr Nemesis.
It is unclear what the fate of Uncanny X-Force will be at this point. Rick Remender recently announced his departure from the title, but editor Tom Brevoort has also hinted at multiple X-Force titles.
Cable and X-Force was teased last week with the word "Wanted".
Hopeless is also working on Avengers Arena for Marvel NOW!
Cable and X-Force #1 will debut in December.