Psylocke will lead the team in Ultimate Comics Ultimates writer Sam Humphries and Wolverine artist Ron Garney's new Marvel NOW! title.
"After the shocking end to the previous group known as X-Force, the mutant known as Psylocke recruits her own clandestine group of operatives - Storm, Puck and Spiral - for missions so important - and so bloody - no-one can know the truth," said the publisher.
"But when the time traveller known as Bishop returns to the present, he puts this new X-Force in his sights and won't rest till he finds them. But just why does this former ally of the X-Men now hunt his former teammates? The answer will leave you speechless."
Uncanny X-Force will run alongside the newly announced Cable and X-Force.
The title was previously teased with the word "Killers".
"Uncanny X-Force carries on the X-Force tradition of bold, unique storytelling with a surprising team lineup and an unpredictable master plan," said Marvel editor-in-chief Axel Alonso.
"Sam and Ron are committed to not only bringing fans one of the most visceral and action packed series on stands, but also showing the consequences of this violence for fans, creating a book that has a lot to say about the world we live in today. With a lot of explosions."
Rick Remender recently announced his departure from the acclaimed Uncanny X-Force title.
Uncanny X-Force will relaunch with a new #1 issue in January 2013.