The Game of Thrones creator added that he would demand various conditions before working for Marvel Comics on the character.
"I think the character I would have most fun writing would be Doctor Strange, who has always been one of my favourites," Martin told MTV Geek at Worldcon.
"Before I would ever do that, I would have to have my lawyers to meet with Marvel's lawyers and work out an absolutely iron-clad contract that would say whatever I did in the story would continue to be canon forever, and would never be retconned, rebooted or reimagined out of the universe when some later writer decided to mess around with it.
"Because I hate that, I hate - I've always hated reboots and retcons and the fact that a writer comes in and undoes what a previous writer did and, you know, brings dead characters back to life, kills new characters that weren't intended to die. That's the one thing I don't like about comics. That drives me crazy."
Martin said that he would separate Doctor Strange from the majority of the Marvel Universe and focus on his work protecting existence from powerful outside influences such as "Cthulhu, the Great Old Ones and the Dread Dormammu".
"That was when Doctor Strange was at his best, when Lee and Ditko were doing him in just that manner."
Watch the full interview below: