Writer Paul Jenkins will team up with artist Carlos Magno for the project, which sees superheroes fight to the death.
The comic, described as a "dark, psychological deconstruction of the superhero genre", sees the world's superheroes imprisoned by a mysterious supervillain who forces them to go head to head in an arena.
BOOM! is billing the series as "the superhero battle royale you can't get from Marvel or DC".
However, Marvel Comics recently unveiled a similarly-themed title in the shape of Avengers Arena, which will also see heroes forced into a fight to the death by a villain.
Deathmatch #1 will be available on December 26.