The publisher confirmed rumours that Brian Michael Bendis and Steve McNiven would tackle Guardians as part of the Marvel NOW! initiative.
Nova will reunite frequent collaborators Jeph Loeb and Ed McGuinness, who most recently worked together on Avengers: X-Sanction.
Guardians will feature the surprise inclusion of Iron Man alongside Star-Lord, Gamora, Drax, Groot and Rocket Raccoon, it was announced during Marvel's Cup O' Joe panel at New York Comic Con.
Nova was confirmed to centre around the newly-introduced Sam Alexander, with Richard Rider still dead following the events of The Thanos Imperative.
"Everything that happened in the [Dan] Abnett and [Andy] Lanning stories was so gigantic and enormous," said Loeb.
"The Nova Corps is gone. This is a story in a very Marvel way about how an ordinary kid has something happen to him in an extraordinary way."