Writer Scott Gimple and artist Mark Texeira will collaborate on the five-issue weekly miniseries, which will launch in January.
The title will see Frank Castle going up against villain Johnny Nightmare, whose murder of soldier Jake Niman's family bears a disturbing resemblance to the death of Frank's own wife and children.
"There are mobsters aplenty in this story, but the central baddie Frank will face is Johnny Nightmare, a super strong, psychotic villain with regenerative powers," Gimple told Marvel.com. "The Punisher can shoot him, stab him, try to blow him up and it'll just make him stronger.
"Jake's put into a coma from his injuries, but just like Frank, he survives the attack," he continued. "While Frank is hunting down Jake's family's killers, he learns more about Jake from his blog entries during his time serving in Afghanistan.
"Jake's story is complicated, and it forms the picture of someone very different from Frank in many ways, but in other, frightening ways, very much the same."
Punisher: Nightmare was first mentioned in 2009.