The public can vote online for the honours, which are named for the Golden State Comic-Con founder.
Ed Brubaker, Geoff Johns, Mark Waid, Robert Kirkman and Scott Snyder have been shortlisted for 'Writer of the Year'.
Greg Capullo, Ivan Reis, J.H. Williams III, Paolo Rivera, Ryan Ottley and Ryan Stegman are in line for 'Penciler of the Year'.
The 'Continuing Series of the Year' category features Amazing Spider-Man, Batman, Daredevil, Saga and The Walking Dead.
Detroit native Dorf's event later evolved into San Diego Comic-Con International.
The prizes will be presented on October 27 at Detroit FanFare.