The actor, who has played the Norse god on-screen twice, penned a letter to the title's writer Kieron Gillen to praise his work on the series.
"You and I see Loki the same way. He's one dark, anarchic, bottomless black hole of rage, hatred, pity and pain," Hiddleston wrote.
"An exiled outcast, a lost and lonely agent of chaos, who wouldn't know what to do with familial forgiveness if it walked up to him in the street and slapped him in the face.
"I've had as much fun playing him as you've clearly had writing up. I know your run on Journey Into Mystery has been so hugely popular. What an enormous honour to share Loki's legacy with you. Here's to bringing Norse back."
Gillen's run on Journey Into Mystery concluded with this week's issue #654. Hiddleston's note appears on the letters page of the comic.