The writer has said that he does not know why the Image Comics book was temporarily listed as "under review" on the US branch of the online retailer, reports Robot 6.
"I've always loved Amazon, but maybe this incident should serve as a reminder that the best place to buy graphic novels is still your friendly neighbourhood local comics store," Vaughan said in a statement.
"Saga exists only because retailers gave it so much support, and they were kind enough to order a metric ass-load of our trades, so they should still have copies on their shelves when you swing by on Wednesday.
"But if they've already sold out, Image still has a few extras stashed down in Kirkman's basement, and good retailers can order you up a fresh one immediately. And if you're still on the fence about picking up our filthy sci-fi/fantasy epic, you can always read our double-sized first issue in its entirety for FREE right here. Then we return monthly with Chapter Seven in two short weeks!"
Amazon's copies of Saga are rumoured to have been heat warped, resulting in their temporary unavailability on the site.