The announcement has debunked rumours that the sidekick will replace Peter Parker as Spider-Man.
The five-issue series will be written by Joshua Hale Fialkov with art by Nuno Plati.
Alpha was recently depowered by Parker in a story produced by the pair for Amazing Spider-Man #694.
"He was a freak and then he became famous, and now he's infamous and powerless essentially as far as the world knows," Fialkov told USA Today.
"He's that creepy kid who used to be on a sitcom when he was 5... He's been demoted from this awesome life to nothing. All the cool stuff is gone."
A new web slinger is in line to take centre stage in the Marvel NOW! title The Superior Spider-Man. His identity remains a mystery.
Alpha #1 will debut in February.