The initiative will see 100 covers of Marvel Comics' Fantastic Four #600 - illustrated by some of the biggest names in the business - auctioned to raise money for the non-profit organisation.
The creators involved include Mike Allred, Chris Bachalo, Tom Brevoort, Giuseppe Camuncoli, Alan Davis, Terry Dodson, Steve Epting, Adam Kubert, George Perez, Mike McKone, Tim Sale and Chris Samnee.
Former subjects of '100 Projects' include Justice League of America, Ultimate Spider-Man and Wolverine: Weapon X.
Walking Dead #100 is also in line to receive the same treatment.
Monkeybrain Comics recently announced that its November profits would go to the charity, which offers financial support to comic book creators.
'Fantastic Four 100 Project' will launch on eBay from November 6 under the seller username Hero Initiative, with a collection following on November 21.