Marvel Comics has previewed the artwork from Olivier Coipel for the landmark issue.
The long-running series will conclude with the issue, to be replaced by the Marvel NOW! title Superior Spider-Man, which will feature a new, undisclosed character in the role of the hero.
Coipel offers a classic image of Spider-Man swinging above Manhattan. It joins previously-revealed variants from Joe Quesada and Marcos Martin.
Writer Dan Slott's and artist Humberto Ramos's issue will conclude the long-running struggle between Peter Parker and his nemesis Doctor Octopus.
It will feature extra stories from JM DeMatteis, Giuseppe Camuncoli, Jen Van Meter and Stephanie Buscema.
Amazing Spider-Man #700 will arrive on December 26.