The comic, which tells the story of a troubled Joy Division fan thrust into the centre of an Aztec war, published three issues before hitting a year-long delay.
"The whole Sacrifice team has been working hard this year to allow us to return to Sacrifice without additional delays," said Humphries.
"Issue #4 is ready to go to the printer, issue #5 is completely drawn, and Dalton is hard at work on issue #6. We're well within schedule to ship the final issue in March. The book is looking better than ever - we thank our awesome retailers and devoted readers for their patience."
Humphries is best known for penning John Carter: Gods of Mars and Ultimate Comics: The Ultimates for Marvel, as well as Higher Earth for BOOM! Studios.
He is currently writing Marvel's upcoming Uncanny X-Force series, which is due to debut on the same day as Sacrifice #4.