The Marvel NOW! series will emerge from the first arc of the writer's All-New X-Men.
Cyclops, Magneto, Emma Frost and Magik will form the core of a team that aims to help the new mutants appearing following the events of Avengers Vs. X-Men.
"They reach across the world to rescue, save, train, rescue the new mutants that are popping up all over the place. It gives us a fantastic opportunity to re-establish what mutants mean in this new world," he said during Marvel's Next Big Thing press conference.
He promised a "Doctor Doom level villain" who has not fought the X-Men before.
Bendis compared the backwards-looking All-New X-Men to Uncanny, which is set firmly in the present.
He addressed Chris Bachalo's redesign of the characters' costumes, specifically the dramatic change for Emma Frost.
"It will still express who she is physically, because it's an important part of her, but it'll be who she sees herself as," he said.
Marvel Comics' Uncanny X-Men #1 and #2 will arrive in February.