The Hysteria creator will take over art duties from Tony Moore in April, Comic Alliance reports.
Gerry Duggan and Brian Posehn will continue to co-write the Marvel NOW! title, but it has not been confirmed whether Hawthorne will handle the book on a rotation basis with Moore.
Marvel Comics has announced several other changes to its art teams of late, with Walt Simonson joining Indestructible Hulk, Phil Noto taking on Thunderbolts and Humberto Ramos boarding Superior Spider-Man in April.
Arthur Adams has provided a teaser illustration for Hawthorne's Deadpool tenure, depicting the 'Merc With a Mouth' on the brink of being crushed by an ice cream truck.
Deadpool was rebooted in November as part of the Marvel NOW! initiative.