The publisher has also revealed interior artwork from the Brian Bendis-penned series, which features illustrations from Bryan Hitch, Brandon Peterson and Carlos Pacheco.
Age of Ultron will run for 10 issues, with Hitch illustrating the first five and Peterson and Pacheco dividing the remainder up between them. Three issues will be released in March and three in April, before the title becomes bi-weekly.
The storyline sees the classic villain destroy humanity and defeat most of the world's heroes, leaving a team comprised of Wolverine, Emma Frost, Invisible Woman, Taskmaster, Beast, She-Hulk, Luke Cage, Spider-Man, and Moon Knight left to oppose him.
"Age of Ultron is about Ultron, one of our biggest villains ever, finally fulfilling his destiny, which is taking the Earth," said Bendis. "From the very first page, Ultron has taken the Marvel Universe and everything is changed.
"There is a shocking amount of destruction and devastation. It started in Avengers, but it's meant to be a Marvel Universe book. It starts everyone. This was never supposed to be my last Avengers story, it was always meant to be a Marvel Universe event."
Age of Ultron #1 ships in March this year.