Paul Jenkins and Jae Lee's hit series will be the eighth Marvel title to be given the motion treatment by Shout! Factory, following the likes of Iron Man: Extremis, Black Panther and Astonishing X-Men: Unstoppable.
Inhumans, which follows a group of genetically-enhanced beings fighting to protect their island kingdom of Attilan, ran for 12 issues between 1998 and 1999.
A movie based on the property was rumoured to be in the planning stages two years ago, but there have been no developments since.
Marvel Studios previously confirmed that Ant-Man and Doctor Strange movies will form part of its 'Phase Three' line-up.
The Inhumans motion comic will be available on DVD from April 23.