The news follows the digital comics giant's move to establish a European base in Paris to take advantage of the flourishing continental base there.
To mark the agreement, comiXology will add French language support to its Walking Dead digital comics app and launch a dedicated Lanfeust of Troy application with the publisher.
The distributor will have a presence at France's Angoulême International Comics Festival, which is the second largest comics festival in the world.
comiXology's iPad app was the third highest-grossing of 2012 and recently announced that it had sold over two billion pages of comics.
Delcourt's entire catalogue will gradually be added to comiXology's library throughout the year.