Robert Kirkman's zombie series took the number one spot with The Walking Dead Compendium One, while other entries in the series occupied the next three spaces.
Viz Media's manga title Rosario+Vampire Season II Vol. 8 claimed fourth place, while Marvel Avengers: The Ultimate Character Guide hardcover gave the world's top comics publisher its only entry on the chart.
Manga upped its presence from four titles last month to five in April, with books from Yen Press and Kodansha Comics also making the grade, ICv2 reports.
A Game of Thrones: The Graphic Novel Volume 1, adapted from the George R.R Martin novels, came in 16th, while Dark Horse Comics' Avatar: The Last Airbender sat in 13th.
Sailor Moon, which topped the chart in the opening months of 2012, had just one entry in April with Volume 4.