The show's writer and producer Roberto Aguirre-Sacasa will pen the four-issue arc for Archie Comics, teaming up with series artist Dan Parent.
"I've been wanting to write something for Archie Comics forever and my favourite Archie stories have always been those weird crossovers like Archie Meets the Punisher, and Archie Meets KISS," said Aguirre-Sacasa.
"I thought, Archie Meets Glee would be a great crossover since they're both set in high schools, they're both optimistic, they both involve singing... My boss Ryan [Murphy, co-creator of Glee] loved the idea and that started the process."
Aguirre-Sacasa has prior experience writing for comics, having penned several titles for Marvel in the past. He also helped rework the script for the Broadway musical Spider-Man: Turn off the Dark.
Archie Meets Glee will be released in 2013.