IDW Publishing is planning an event in which The Doctor, Rory and Amy encounter Captain Picard and his crew, Bleeding Cool reports.
Star Trek has crossed over with other comic properties on several occasions, including IDW's recent Infestation series.
Doctor Who has never officially crossed over with another sci-fi property in mainstream comics.
A creative team for the crossover project has not been announced, though it has been speculated that Tony Lee could be involved as the scribe is due to appear with IDW at a London Super Comic Con panel at the end of the month.
The Doctor Who/Star Trek crossover is expected to debut in May.