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Sci Fi Wire reports that the casting development will see the siblings star together in the fourth season episode 'Lady Killer', which airs on NBC in April. Rosanna Arquette, best known for her film roles in Desperately Seeking Susan and Pulp Fiction, will play a "dangerous femme fatale" responsible for the deaths of two young men.
In the third season of Medium, Patricia Arquette was joined by her younger brother David, although he did not appear in front of the camera. Instead, he directed the episode '1-900-Lucky'.
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